Optimizing oral immunotherapy to cow milk protein: a decision analysis
نویسندگان
چکیده
Methods We used Markov transition models to compare the expected lifetime gain in quality-adjusted life years (QALYs) of OIT to CMP versus strict avoidance of CMP. Models were run for base cases of 6to 16-yearold children with CMA requiring strict CMP avoidance. Rates of transition to the partial or full desensitization and complete tolerance states, utilities for each state, and disutilities and durations of reactions were determined from the literature. Participants progressed through the OIT states in order but could regress to an earlier state or repeat OIT.
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متن کاملClinical Predictors for Favorable Outcomes in an Oral Immunotherapy Program for IgE-Mediated Cow's Milk Allergy.
BACKGROUND Avoidance strategies in patients with cow's milk allergy occasionally fail to protect these patients from inadvertent exposures, leading to life-threatening reactions. OBJECTIVE To assess the safety and efficacy of milk oral immunotherapy as an alternative therapeutic strategy. METHODS Patients (n = 280, >4 years old) with IgE-mediated cow's milk allergy were enrolled into a milk...
متن کاملOral Immunotherapy for Food Allergy: A Spanish Guideline. Egg and Milk Immunotherapy Spanish Guide (ITEMS GUIDE). Part II: Maintenance Phase of Cow Milk (CM) and Egg Oral Immunotherapy (OIT), Special Treatment Dosing Schedules. Models of Dosing Schedules of OIT With CM and Egg.
BACKGROUND AND OBJECTIVE Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the...
متن کاملPD28 - Is other bovid mammals milk tolerated by children who have been submitted to cow’s milk oral immunotherapy?
Introduction Caseins cross-reactivity rises up to 90% between cow’s milk (CM) and other bovid milks. There are few studies on tolerance to other mammals milk in patients submitted to cow’s milk oral immunotherapy (CMOIT). AIMS: To determine the percentage of patients whom after CMOIT tolerate water buffalo (WB), goat and sheep’s milk proteins (MP). To describe immunologic features which can pre...
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INTRODUCTION Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. OBJECTIVES To develop a clinical guide on OIT based on the available scientific evidence ...
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